Judy asked a question about a post I did earlier today - Playing with Blocks. You will want to take a look at that and at her comment before you read this post. That is, if you want this post to make sense; otherwise go right ahead and read this now.
If it is, then the answer is yes you can. If it's not, then the answer is still yes you can.
The answer is still yes.
You can do anything you want is the most important rule I know for designing a quilt.